Ozempic® (semaglutide) has gained popularity for its weight loss benefits, but users have increasingly reported a side effect known as “Ozempic face.” This guide explores what it is, why it occurs, and the most effective, medically sound treatments available today.
What Is Ozempic Face?
“Ozempic face” is a colloquial term used to describe the facial volume loss, sagging, and skin laxity that some individuals experience after rapid weight loss associated with Ozempic (semaglutide) treatment. Originally approved to manage Type 2 diabetes, Ozempic is now widely used off-label for weight loss due to its appetite-suppressing effects.
Clinical Appearance Includes:
● Hollow cheeks
● Loose or sagging skin
● Aged or gaunt appearance
● Prominent facial bones
This is not a direct side effect of the drug but rather a result of fat loss, especially subcutaneous fat in the face, which can lead to changes in facial contours.
Reference:
- American Academy of Dermatology. Fat loss from rapid weight loss or GLP-1 agonists like Ozempic.
Why Does It Happen?
Rapid weight loss triggers changes in soft tissue volume across the body, including the face. As facial fat diminishes, skin may struggle to retract due to reduced collagen, elastin, and natural hydration—especially in individuals over 40. The result is premature aging signs and a tired appearance.
Non-Surgical Treatments for Ozempic Face
Dermal Fillers
One of the most common responses to facial volume loss is hyaluronic acid-based fillers (e.g., Juvederm®, Restylane®), which restore contour and plumpness.
● Areas treated: Mid-cheeks, nasolabial folds, temples
● Duration: 6 to 18 months
● Pros: Immediate results
● Cons: Temporary, risk of bruising or lumps
Biostimulators (Sculptra®, Radiesse®)
These stimulate collagen production, improving skin thickness and volume gradually.
● Mechanism: Induces fibroblast activity to rebuild structural proteins
● Duration: Results last 1–2 years
● Ideal for: Long-term facial rejuvenation
Ultrasound Skin Tightening (e.g., Sofwave™)
Sofwave™ is a non-invasive ultrasound-based treatment approved by the FDA to lift and tighten skin.
● Mechanism: Delivers Synchronous Ultrasound Parallel Beam (SUPERB™) energy to stimulate collagen at the dermal level
● Treatment zones: Jawline, cheeks, brow
● Benefits: No downtime, suitable for all skin types, minimal discomfort
● Sessions needed: 1–2, spaced months apart
Sofwave™ is particularly effective when skin laxity is more prominent than fat loss.
Microneedling with Radiofrequency (RF)
Devices like Morpheus8 combine microneedling with RF to tighten skin and improve texture.
● Effect: Boosts collagen and elastin
● Pros: Improves elasticity and reduces crepiness
● Cons: Requires multiple sessions
Laser Skin Resurfacing
Fractional lasers (e.g., Fraxel®) help restore skin quality by stimulating dermal remodeling.
● Best for: Fine lines, skin tone improvement
● Downsides: Mild peeling and downtime
Surgical Solutions
If non-surgical methods fall short, facial fat grafting or a lower face lift may be considered for advanced cases. These are more invasive but offer long-lasting structural rejuvenation.
Skincare and Lifestyle Enhancements
● Topical Retinoids: Stimulate cell turnover and collagen production
● Peptides & Antioxidants: Help in tissue repair and defense
● Hydration & Diet: A protein-rich, collagen-supporting diet can boost results
● Sleep and Sun Protection: Sleep helps tissue recovery, while SPF preserves skin health
Other Notable Technologies and Brands
| Technology | Brand/Device | Type | Notes |
| Ultrasound | Sofwave™ | Non-invasive | Targets collagen production without downtime |
| RF Microneedling | Morpheus8, Secret RF | Minimally invasive | Best for fine tightening and texture |
| Biostimulators | Sculptra®, Radiesse® | Injectable | Stimulates natural collagen production |
| Dermal Fillers | Juvederm®, Restylane® | Injectable | Immediate volume restoration |
| Fractional Lasers | Fraxel®, Halo® | Laser resurfacing | Enhances texture and firmness |
Conclusion
“Ozempic face” is a manageable and reversible condition with the right combination of medical aesthetics, skincare, and non-surgical innovations. With advanced treatments like Sofwave™ and a strategic approach guided by a board-certified dermatologist or cosmetic physician, patients can restore youthful contours safely and effectively.
References
- American Academy of Dermatology Association. “Ozempic Face: What You Should Know.” https://www.aad.org/public/cosmetic/younger-look/ozempic-face
- Sofwave™ Official Site – https://sofwave.com/
- Mayo Clinic. “Facial fillers for aging skin.” https://www.mayoclinic.org/tests-procedures/fillers/about/pac-20384926
- American Society for Dermatologic Surgery. “Treatments for facial aging.” https://www.asds.net/skin-experts/skin-conditions/aging-skin
- International Journal of Cosmetic Science. “Collagen remodeling by ultrasound-based devices” (2021).