When we talk about erectile dysfunction (ED) treatments, two medications that frequently come to our mind are Vardenafil and Sildenafil. Both belong to the class of phosphodiesterase type 5 (PDE5) inhibitors and are designed to improve blood flow to the penis, helping achieve erections. However, understanding the distinct differences between these two drugs is crucial for finding the right and most effective solutions for ED.
This blog looks into the differences and similarities between Sildenafil and Vardenafil, and aim to provide readers with the knowledge needed to make the right decisions regarding their treatment options.
Vardenafil And Sildenafil- An Overview
Vardenafil is a medication used to treat erectile dysfunction. It increases blood flow to the penis, enhancing an erection in response to sexual stimulation. It is available under brand names such as Staxyn, Vitara, Vilitra, and Levitra. The commonly available dosage strengths for this medication are 2.5mg, 5mg, 10mg, and 20mg. In severe cases where lower dosages of the medication do not show effective results, higher dosage strength such as Vitara V 60mg is recommended.
Sildenafil is the first PDE5 inhibitor used for the treatment of erectile dysfunction. Commonly recognized by the brand name Viagra and Cenforce, Sildenafil works similarly to Vardenafil by enhancing blood flow to the penis. Sildenafil is widely used and has a well-established safety and efficacy profile.
People new to ED medications should start with a lower dose such as Cenforce 100mg. This dose strength can later gradually increased based on the severity of the condition and how your body respond to the treatment.
Sildenafil Vs Vardenafil – Key Similarities
The key similarities between Sildenafil and Vardenafil include-
Mechanism of Action
Both drugs are phosphodiesterase type 5 (PDE5) inhibitors. They work by increasing blood flow to the penis during sexual arousal. This helps in getting and maintaining a firm erection.
Clinical Use
Both Vardenafil and Sildenafil are primarily prescribed for the treatment of erectile dysfunction. It is a condition that is characterized by the inability to get and maintain an erection.
Difference Between Sildenafil And Vardenafil
The key distinctions between Sildenafil and Vardenafil are as follows:
Duration of Action
The effect of Sildenafil lasts up to 4 hours, whereas that of Vardenafil lasts about 5 to 7 hours.
Cost Of The Medication
The cost of Sildenafil brand drugs starts at $0.83 per pill. In comparison, the cost of Vardenafil brand drugs begins at $1.12 per pill at IyrinHealth Care.
Chemical Structure
They are different compounds, which can affect their absorption and the duration they remain in the body.
Lower Risk of Side Effects
The primary advantage of Vardenafil over Sildenafil is its minimal impact on phosphodiesterase-5. This minimizes the risk of altered color perception, a rare side effect of Sildenafil.
Food Interaction
Sildenafil’s effectiveness can be reduced when taken with a high-fat meal. Vardenafil is less affected by food.
Approved Uses
In addition to treating erectile dysfunction, Sildenafil is FDA-approved for treating pulmonary arterial hypertension (PAH). It is a condition that causes increased blood pressure in the arteries of the lungs. Sildenafil helps improve exercise tolerance and may delay the progression of the condition in adults.
Onset of Action
Sildenafil typically takes around 30 minutes to start working, although this time may vary among individuals. Whereas, the onset of action for Vardenafil is 30 to 60 minutes.
Viagra vs. LevitraEvaluating Efficacy For Erectile Dysfunction
Sildenafil and vardenafil are widely used to treat erectile dysfunction, functioning as phosphodiesterase type 5 (PDE5) inhibitors to enhance blood flow to the abdomen.
Both medications have a rapid onset of action, thus allowing for spontaneous sexual activity.
The Impact of Sildenafil on Men’s Health and Quality of Life
Sildenafil, widely recognized for its role in treating erectile dysfunction, has proven to significantly improve the quality of life and satisfaction for many men. With over 30 million men treated globally, the extensive research surrounding this medication emphasizes its importance in healthcare.
With a favorable safety profile, it is well-tolerated and causes minimal side effects, making it a trusted option among healthcare providers. An extensive amount of evidence,over 2,600 studies published in Medline as of July 2006,supports its efficacy and safety in treating ED .
Vardenafil For Treating ED
Vardenafil is a medication used to help men with erectile dysfunction. Studies have shown that Vardenafil can significantly improve erectile function in men with varying levels of ED, from mild to severe. Men using vardenafil often report better results than those using a placebo.
Patients have experienced greater improvements in their ability to engage in sexual activity, including better penetration and maintaining an erection.
Clinical studies have also shown that it is effective in older men, where erectile dysfunction (ED) is more common.
Recent data involving patients from 47 countries highlighted the positive outcomes associated with Vardenafil. Many patients reported being satisfied or very satisfied with its efficacy [5].
Vardenafil Vs Sildenafil Dosage Guidelines
Sildenafil is prescribed at a standard starting dose of 50 mg, while Vardenafil generally begins at a dose of 10 mg. For best efficacy, these medications should be taken 30 to 60 minutes before sexual activity.
Both Sildenafil and Vardenafil are designed for oral administration and should be swallowed with water. Additionally, it is essential to note that both medications can be taken once daily, as directed by a healthcare professional.
For specific dosing recommendations and adjustments, please consult your doctor.
Vardenafil Vs Sildenafil Side Effects
Both Vardenafil and Sildenafil can cause similar side effects, including headache, nausea, dizziness, blurred vision, flushing, nasal congestion, numbness, chest pain, and shortness of breath.
The following side effects are specific to each medication:
- For sildenafil, side effects may include muscle pain, sensitivity to light, anxiety, painful urination, stomach upset, nervousness, increased sweating, thirst, and sudden weakness.
- For vardenafil, side effects may include difficulty swallowing, dizziness, a fast heartbeat, watery eyes, shivering, trouble sleeping, neck pain, loss of appetite, and weakness.
These side effects are rare and distinct to each drug and should be considered when discussing their use.
Drug Interactions
Vardenafil and Sildenafil, when taken with other medications and supplements, can result in drug interactions. This may lower its effectiveness and increase the risk of side effects.
According to data from the Drugs website, Vardenafil has more potential interactions with medications compared to Sildenafil.
Some of the medications that should not be taken with Vardenafil and Sildenafil are listed below.
| Vardenafil | Acetazolamide, adagrasib, boceprevir, citalopram, dofetilide, dolasetron, grepafloxacin, halofantrine, haloperidol, isosorbide, mobocertinib, nitroglycerin, ozanimod, panobinostat, papaverine, ritonavir, and saquinavir. |
| Sildenafil | Amprenavir, amyl nitrite, butabarbital, clarithromycin, erythromycin, etravirine, fexinidazole, imatinib, ketoconazole, lonafarnib, mitotane, nitroglycerin, phenytoin, rifampin, and secobarbital. |
Choosing The Right Option
When considering treatment options for ED, it is vital to select a medication that aligns with your health condition and needs. Here are a few key factors to consider when choosing between Vardenafil and Sildenafil.
Personal Health History
Vardenafil is effective for men with ED, particularly if you have certain health conditions such as diabetes or cardiovascular issues. Sildenafil, on the other hand, is also effective for ED and is often the first-line treatment for PAH.
Underlying Health Conditions
Specific health issues may influence the choice of medication. For example, Vardenafil may be preferred in men with diabetes due to its effect on the heart.
Preferences
Sildenafil (Viagra) is widely recognized and may be more familiar to patients, often being the first ED medication prescribed. However, Vardenafil may be preferred if you want a longer duration of action and effectiveness, allowing for more spontaneity.
Which Is Better Sildenafil Or Vardenafil- Our Final Thought
When weighing the options between Sildenafil and Vardenafil for treating erectile dysfunction, both medications are proven to be effective. They are both FDA-approved ED medications that work within 30 minutes of intake; however, Vardenafil has a longer duration of action.
Some studies suggest that Vardenafil may be more potent, which makes it a compelling choice for many. A recent study comparing Vardenafil and Sildenafil found that both medications were well tolerated with minimal side effects. However, Vardenafil demonstrated superiority over Sildenafil, indicating it may be more effective for some patients.
Additionally, Vardenafil is less affected by food intake, allowing for more flexibility when taken with meals.
Determining the most suitable treatment for erectile dysfunction can be challenging, as it often depends on individual preferences and specific health considerations. Therefore, it is essential to consult a healthcare provider to explore the options and identify the best approach for your condition.
References
- Comparison of clinical trials with sildenafil, vardenafil, and tadalafil in erectile dysfunction, PubMed.
- Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects, and dose proportionality, NCBI.
- Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence, NCBI.
- Vardenafil: A review of its use in erectile dysfunction, PubMed.
- Vardenafil for the treatment of erectile dysfunction: an overview of the clinical evidence, NCBI.
- Vardenafil (Oral Route) Side Effects, MayoClinic.
- Sildenafil, MedlinePlus.
- Sildenafil (Oral Route), Mayoclinic.
- Vardenafil Interactions, Drug.
- Sildenafil Interactions, Drug.
- Comparing Vardenafil and Sildenafil in the Treatment of Men with Erectile Dysfunction and Risk Factors for Cardiovascular Disease: A Randomized, Double‐Blind, Pooled Crossover Study, ScienceDirect.
Faq
Can you take Vardenafil and Sildenafil together?
No, it is not advisable to take Vardenafil and Sildenafil together.
Is Vardenafil more potent than Viagra?
Vardenafil (Levitra) and Sildenafil (Viagra) are similar in effectiveness for erectile dysfunction, with some studies suggesting vardenafil may be slightly more potent. However, individual responses vary, so consulting a healthcare professional is best for choosing the right option.
How long does Levitra last?
The effects of Levitra, the brand drug of Vardenafil, lasts for 5 to 7 hours.
What is the recommended dose of Sildenafil?
Beginners are recommended to start with a lower dose, such as 50mg.
Can you take Sildenafil more than once a day?
No, it is not advisable to take Sildenafil more than once a day unless specifically prescribed by your doctor.
Which among Viagra vs Levitra hardness potency is better?
Both Vardenafil (Levitra) and Sildenafil (Viagra) are effective in making you hard. However, the effect of Vardenafil lasts longer than Sildenafil.
How long does Sildenafil last?
The action of Sildenafil lasts for about 4 hours.
How long can Sildenafil side effects last?
The side effects of Sildenafil are usually mild and temporary and may last a few days to a few weeks.